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Acquired angioedema
CicardiandZanichelliAllergy,AsthmaClinicalImmunology2010,6:14
/content/6/1/14
ALLERGY, ASTHMA CLINICAL
IMMUNOLOGY
REVIEW
OpenAccess
Acquiredangioedema
MarcoCicardi*,AndreaZanichelli
Abstract
Acquiredangioedema(AAE)ischaracterizedbyacquireddeficiencyofC1inhibitor(C1-INH),hyperactivationofthe
classicalpathwayofhumancomplementandangioedemasymptomsmediatedbybradykininreleasedbyinap-
propriateactivationofthecontact-kininsystem.Angioedemarecursatunpredictableintervals,lastsfromtwoto
fivedaysandpresentswithedemaoftheskin(face,limbs,genitals),severeabdominalpainwithedemaofthe
gastrointestinalmucos
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