Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion a proof of concept study on metabolic and vasomotor effects.docVIP
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Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion a proof of concept study on metabolic and vasomotor effects
Derwalletal.CriticalCare2011,15:R51
/content/15/1/R51
RESEARCH
OpenAccess
Administrationofhydrogensulfidevia
extracorporealmembranelungventilationin
sheepwithpartialcardiopulmonarybypass
perfusion:aproofofconceptstudyonmetabolic
andvasomotoreffects
MatthiasDerwall1,2*?,RolandCEFrancis1?,KotaroKida1,MasahikoBougaki1,EttoreCrimi1,ChristopheAdrie1,
WarrenMZapol1,FumitoIchinose1
Abstract
Introduction:Althoughinhalationof80partspermillion(ppm)ofhydrogensulfide(H2S)reducesmetabolismin
mice,doseshigherthan200ppmofH2Swererequiredtodepressmetabolisminrats.Wethereforehypothesized
thathigherconcentrati
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