Ageing, autoimmunity and arthritis Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system.docVIP

Arthritis Research Therapy Vol 5 No 6 Fül?p et al. Review Ageing, autoimmunity and arthritis Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system Tamàs Fül?p Jr1,2,3, Anis Larbi1,2, Gilles Dupuis2,4 and Graham Pawelec5 1Research Center on Ageing, Sherbrooke Geriatric University Institute, University of Sherbrooke, Quebec, Canada 2Graduate Program in Immunology, University of Sherbrooke, Quebec, Canada 3Geriatric Service, University of Sherbrooke, Quebec, Canada and Geriatric Division, University of Franche-Comté, Faculty o