Association of BDNF gene polymorphism with asthma in polish children.docVIP

ORIGINALARTICLE AssociationofBDNFGenePolymorphismWithAsthmain PolishChildren AleksandraSzczepankiewicz,PhD,1,2 AnnaBre?borowicz, Prof.,MD,PhD,2 PaulinaSobkowiak,MD,PhD,2 andAnnaPopiel,MD,PhD2 INTRODUCTION sthmaisthemostcommonchronicdiseaseofchildhood andischaracterizedbythereversibleair?owobstruction Abstract: Allergic asthma is associated with changes in neuronal A control in the airways that modulate in?ammation and airway hyperresponsiveness.Thelinkbetweenin?ammationandneuronal dysfunctionisprovidedmainlybyneurotrophins,inparticularBrain Derived Neurotrophic Factor (BDNF). In humans, si