Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC).docVIP
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Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC)
Jietal.DiagnosticPathology2011,6:48
/content/6/1/48
RESEARCH
OpenAccess
Associationofpromotermethylationwith
histologictypeandpleuralindentationin
non-smallcelllungcancer(NSCLC)
MeijuJi1?,YongZhang2?,BingyinShi1andPengHou1*
Abstract
Background:Lungcancerisamajorcauseofdeathworldwide.Genepromotermethylationisamajorinactivation
mechanismoftumor-relatedgenes,someofwhichcanbeservedasabiomarkerforearlydiagnosisandprognosis
evaluationoflungcancer.
Methods:Wedeterminedthepromotermethylationof6genesusingquantitativemethylation-specificPCR(Q-
MSP)techniquein96clinicallywell-characterizednon-smallcell
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