Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC).docVIP

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Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC).doc

Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC)

Jietal.DiagnosticPathology2011,6:48 /content/6/1/48 RESEARCH OpenAccess Associationofpromotermethylationwith histologictypeandpleuralindentationin non-smallcelllungcancer(NSCLC) MeijuJi1?,YongZhang2?,BingyinShi1andPengHou1* Abstract Background:Lungcancerisamajorcauseofdeathworldwide.Genepromotermethylationisamajorinactivation mechanismoftumor-relatedgenes,someofwhichcanbeservedasabiomarkerforearlydiagnosisandprognosis evaluationoflungcancer. Methods:Wedeterminedthepromotermethylationof6genesusingquantitativemethylation-specificPCR(Q- MSP)techniquein96clinicallywell-characterizednon-smallcell

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