Asthma and Therapeutics Recombinant Therapies in Asthma.docVIP

Asthma and Therapeutics Recombinant Therapies in Asthma Donald W. Cockcroft, MD, FRCPC Abstract History Numerous recombinant therapies are being inves- tigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti–immunoglobulin (Ig)E (omal- izumab, Xolair) markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demon- strated benefit by improved symptoms and lung function and a reduction in corticosteroid re