Asthma and Therapeutics Recombinant Therapies in Asthma.docVIP

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Asthma and Therapeutics Recombinant Therapies in Asthma.doc

Asthma and Therapeutics Recombinant Therapies in Asthma

Asthma and Therapeutics Recombinant Therapies in Asthma Donald W. Cockcroft, MD, FRCPC Abstract History Numerous recombinant therapies are being inves- tigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti–immunoglobulin (Ig)E (omal- izumab, Xolair) markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demon- strated benefit by improved symptoms and lung function and a reduction in corticosteroid re

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