Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.docVIP
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Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole
Akanumaetal.FluidsandBarriersoftheCNS2011,8:24
/content/8/1/24
FLUIDS AND BARRIERS
OF THE CNS
RESEARCH
OpenAccess
AttenuationofprostaglandinE2elimination
acrossthemouseblood-brainbarrierin
lipopolysaccharide-inducedinflammationand
additiveinhibitoryeffectofcefmetazole
Shin-ichiAkanuma1,YasuoUchida2,SumioOhtsuki2,MasanoriTachikawa2,TetsuyaTerasaki2* and
Ken-ichiHosoya1
Abstract
Background:Peripheraladministrationoflipopolysaccharide(LPS)inducesinflammationandincreasescerebral
prostaglandinE2(PGE2)concentration.PGE2iseliminatedfrombrainacrosstheblood-brainbarrier(BBB)inmice,
andthisproce
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