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Autosomal monoallelic expression in the mouse
Zwemeretal.GenomeBiology2012,13:R10
/2012/13/2/R10
RESEARCH
OpenAccess
Autosomalmonoallelicexpressioninthemouse
LillianMZwemer1,AlexanderZak2,5,BenjaminRThompson2,AndrewKirby1,MarkJDaly1,AndrewChess1,3* and
AlexanderAGimelbrant2,4*
Abstract
Background:Randommonoallelicexpressiondefinesanunusualclassofgenesdisplayingrandomchoicefor
expressionbetweenthematernalandpaternalalleles.Onceestablished,theallele-specificexpressionpatternis
stablymaintainedandmitoticallyinherited.ExamplesofrandommonoallelicgenesincludethosefoundontheX-
chromosomeandasubsetofautosomalgenes,whichhavebeenmostextens
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