Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis.docVIP
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Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis
Charpinetal.ArthritisResearchTherapy2010,12:R194
/content/12/5/R194
RESEARCH ARTICLE
OpenAccess
AutoantibodiestoBRAF,anewfamilyof
autoantibodiesassociatedwithrheumatoid
arthritis
CarolineCharpin1,2,MarielleMartin1,NathalieBalandraud1,2,JeanRoudier1,2,IsabelleAuger1*
Abstract
Introduction:BRAF(vrafmurinesarcomaviraloncogenehomologueB1)isaserine-threoninekinaseinvolvedin
themitogen-activatedproteinkinase(MAPK)signallingpathway,knowntobeimplicatedintheproductionofpro-
inflammatorycytokines.
Wehaveobservedthatserafromrheumatoidarthritis(RA)patientsrecognizetheBRAF’scatalyticdomain,which
encompa
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