B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.docVIP

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B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.doc

B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

Daoussisetal.ArthritisResearchTherapy2012,14:R145 /content/14/3/R145 RESEARCH ARTICLE OpenAccess B-celldepletiontherapyinpatientswithdiffuse systemicsclerosisassociateswithasignificant decreaseinPDGFRexpressionandactivationin spindle-likecellsintheskin DimitriosDaoussis1*?,AthanassiosCTsamandas2?,Stamatis-NickCLiossis1?,IoannisAntonopoulos1,ElliKaratza2, GeorgiosYiannopoulos1andAndrewPAndonopoulos1 Abstract Introduction:Recently,severalstudiesassessingtheclinicalefficacyofrituximab(RTX)insystemicsclerosis(SSc) havereportedencouragingresults.WeaimedatexploringwhetherRTXexertsitsbeneficialeff

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B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.docVIP