Bench-to-bedside review Hypercapnic acidosis in lung injury - from permissive to therapeutic.docVIP

Ijland et al. Critical Care 2010,14:237 /content/14/6/237 RE VIE W Bench-to-bedside review: Hypercapnic acidosis in lung injury - from ‘permissive’ to ‘therapeutic’ Marloes M Ijland*, Leo M Heunks and Johannes G van der Hoeven maximum PaCO and pH associated with permissive Abstract 2 hypercapnia are around 8.9 kPa and 7.2, respectively [2], Modern ventilation strategies for patients with acute lung injury and acute respiratory distress syndrome frequently result in hypercapnic acidosis (HCA), which is regarded as an acceptable side e?ect (‘permissive hypercapnia’). Multiple expe