Bench-to-bedside review The role of C1-esterase inhibitor in sepsis and other critical illnesses.docVIP

Singer and Jones Critical Care 2011,15:203 /content/15/1/203 RE VIE W Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses Mervyn Singer* and Annie M Jones 1 2 the primary regulator of the plasma kallikrein-kinin system as evidenced by a lack of kallikrein inhibitory capability in plasma taken from patients with hereditary angioedema [12] and can also inactivate other proteases, including plasmin and tissue plasminogen activator, although the in vivo s