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BMPR2 expression is suppressed by signaling through the estrogen receptor
Austinetal.BiologyofSexDifferences2012,3:6
/content/3/1/6
RESEARCH
OpenAccess
BMPR2expressionissuppressedbysignaling
throughtheestrogenreceptor
EricDAustin1*,RizwanHamid1,AnnaRHemnes2,JamesELoyd2,TomBlackwell2,ChangYu3,JohnAPhillipsIII1,
RadhikaGaddipati2,SanthiGladson2,EverettGu1,JamesWest2andKirkBLane2
Abstract
Background:Studiesinmultipleorgansystemshaveshowncross-talkbetweensignalingthroughthebone
morphogeneticproteinreceptortype2(BMPR2)andestrogenpathways.Inhumans,pulmonaryarterial
hypertension(PAH)hasafemalepredominance,andisassociatedwithdecreasedBMPR2expression.Thegoalof
thisstudywas
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