原创力文档Blood–brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation.docVIP
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Blood–brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation
Schellenbergetal.FluidsandBarriersoftheCNS2012,9:10
/content/9/1/10
FLUIDS AND BARRIERS
OF THE CNS
RESEARCH
OpenAccess
Blood–brainbarrierdisruptioninCCL2transgenic
miceduringpertussistoxin-inducedbrain
inflammation
AngelaESchellenberg1*,RichardBuist2,MarcRDelBigio3,HenrikToft-Hansen4,5,RezaKhorooshi6,
TrevorOwens6,7andJamesPeeling1,2
Abstract
Background:ThechemokineCCL2hasanimportantroleintherecruitmentofinflammatorycellsintothecentral
nervoussystem(CNS).AtransgenicmousemodelthatoverexpressesCCL2intheCNSshowsanaccumulationof
leukocyteswithintheperivascularspacesurroundingvessels,andwhichinfi
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