Breakdown of the Blood-Ocular Barrier as a Strategy for the Systemic Use of Nanosystems.docVIP

Pharmaceutics 2012, 4, 252-275; doi:10.3390/pharmaceutics4020252 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Hypothesis Breakdown of the Blood-Ocular Barrier as a Strategy for the Systemic Use of Nanosystems Marcelo L. Occhiutto 1, Fatima R. Freitas 1, Raul C. Maranhao 1,2 and Vital P. Costa 3,* 1 Heart Institute, Medical School Hospital, University of S?o Paulo, S?o Paulo 05403-000, Brazil; E-Mails: marceloocchiutto@.br (M.L.O.); fatima.sousa@incor.usp.br (F.R.F.); ramarans@usp.br (R.C.M.) 2 Faculty of Pharmaceutical Science, University of S?o Paulo, S?o Paulo 05508-0