原创力文档C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.docVIP
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C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
Yuanetal.ArthritisResearchTherapy2012,14:R140
/content/14/3/R140
RESEARCH ARTICLE
OpenAccess
C5aanditsreceptorsinhumananti-neutrophil
cytoplasmicantibody(ANCA)-associatedvasculitis
JunYuan1,2,Shen-JuGou1,JingHuang1,JianHao1,MinChen1*andMing-HuiZhao1
Abstract
Introduction:Thecomplementsystemiscrucialforthedevelopmentofantineutrophilcytoplasmicantibody
(ANCA)-associatedvasculitis(AAV).Inparticular,C5aplaysacentralrole.Inthisstudy,plasmaandurinarylevelsof
C5aaswellasrenalC5areceptors(CD88andC5L2)expressionwereinvestigatedinpatientswithAAV.
Methods:Twenty-fourpatientswithAAVintheactivephase,19p
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