原创力文档Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2.docVIP
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Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2
Ikegamietal.GenomeBiology2010,11:R120
/2010/11/12/R120
RESEARCH
OpenAccess
Caenorhabditiseleganschromosomearmsare
anchoredtothenuclearmembranevia
discontinuousassociationwithLEM-2
KohtaIkegami1,TheaAEgelhofer2,SusanStrome2,JasonDLieb1*
Abstract
Background:AlthoughCaenorhabditiseleganswasthefirstmulticellularorganismwithacompletelysequenced
genome,howthisgenomeisarrangedwithinthenucleusisnotknown.
Results:WedeterminedthegenomicregionsassociatedwiththenucleartransmembraneproteinLEM-2inmixed-
stageC.elegansembryosviachromatinimmunoprecipitation.Largeregionsofseveralmegabasesonthearmsof
eachauto
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