Can novel therapeutics halt the amyloid cascade.docVIP

Prins et al. Alzheimer’s Research Therapy 2010,2:5 /content/2/2/5 COMMENTA RY Can novel therapeutics halt the amyloid cascade? Niels D Prins , Pieter Jelle Visser and Philip Scheltens * 1 1,2 1 Recently the ? rst two large trials with drugs that may slow disease progression have been published: a phase 2, passive immunization trial with bapineuzumab; and a phase 3 trial with taren? urbil, a modulator of γ-secretase. Both drugs supposedly interfere with β-amyloid