Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae).docVIP

Valletta et al. BMC Plant Biology 2010, 10:69 /1471-2229/10/69 RESEARCH ARTICLE Open Access Cell-specific expression of tryptophan Research article decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae) Alessio Valletta1, Livio Trainotti2, Anna Rita Santamaria1 and Gabriella Pasqua*1 Abstract Background: Camptotheca acuminata is a major natural source of the terpenoid indole alkaloid camptothecin (CPT). At present, little is known about the cellular distribution of the biosynthesis of CPT, which