Cerebrospinal fluid neopterin an informative biomarker of central nervous system immune activation in HIV-1 infection.docVIP

Hagberg et al. AIDS Research and Therapy 2010, 7:15 /content/7/1/15 REVIEW Open Access Cerebrospinal fluid neopterin: an informative Review biomarker of central nervous system immune activation in HIV-1 infection Lars Hagberg*1, Paola Cinque2, Magnus Gisslen1, Bruce J Brew3, Serena Spudich4, Arabella Bestetti2, Richard W Price4 and Dietmar Fuchs5 Abstract HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the macrophage activation marker