Chitosan Interferon-γ Nanogene Therapy for Lung Disease Modulation of T-Cell and Dendritic Cell Immune Responses.docVIP

ORIGINAL ARTICLE ChitosanInterferon-cNanogeneTherapyforLungDisease: ModulationofT-CellandDendriticCellImmune Responses XiaoyuanKong,MD,GaryR.Hellermann,PhD,WeidongZhang,PhD,PrasannaJena,PhD,MukeshKumar,PhD, ArunaBehera,PhD,SumitaBehera,MSc,RichardLockey,PhD,andShyamS.Mohapatra,PhD The use of chitosan nanoparticles as carriers for expression plasmids represents a major improvement in gene expression technology. We demonstrated previously that treatment with chitosan interferon-c (IFN-c) plasmid deoxyribonucleic acid (DNA) nanoparticles(chitosaninterferon-cnanogene[CIN])ledtoinsituproductionof