Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity.docVIP

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Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity.doc

Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity

Tewarietal.GenomeBiology2012,13:R88 /2012/13/10/R88 RESEARCH OpenAccess Chromatinaccessibilityrevealsinsightsinto androgenreceptoractivationand transcriptionalspecificity AlokKTewari1,GalipGürkanYardimci1,YoichiroShibata1,NathanCSheffield1,LingyunSong1,BarrySTaylor3, StoyanGGeorgiev1,GerhardACoetzee4,5,UweOhler1,6,7,TerrenceSFurey8,GregoryECrawford1,9?and PhillipGFebbo2,10,11*? Abstract Background:EpigeneticmechanismssuchaschromatinaccessibilityimpacttranscriptionfactorbindingtoDNA andtranscriptionalspecificity.Theandrogenreceptor(AR),amasterregulatorofthemalephenotypeandprostate cancerpatho

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