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Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.docVIP

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Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.doc

    Chaietal.ChineseMedicine2010,5:26 /content/5/1/26 REVIEW OpenAccess Circumventionofmulti-drugresistanceofcancer cellsbyChineseherbalmedicines StellaChai1,KennethKWTo2,GeLin1* Abstract Multi-drugresistance(MDR)ofcancercellsseverelylimitstherapeuticoutcomes.AproposedmechanismforMDR involvestheeffluxofanti-cancerdrugsfromcancercells,primarilymediatedbyATP-bindingcassette(ABC)mem- branetransportersincludingP-glycoprotein.Thisarticlereviewstherecentprogressofusingactiveingredients, extractsandformulaefromChinesemedicine(CM)incircumventingABCtransporters-mediatedMDR.Amongthe ABCtransporters,Pgpist

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