Clinical review Ventilator-induced diaphragmatic dysfunction - human studies confirm animal model findings!.docVIP

Jaber et al. Critical Care 2011,15:206 /content/15/2/206 REVIEW Clinical review: Ventilator-induced diaphragmatic dysfunction - human studies con? rm animal model ? ndings! 1,2,3 2,3,4 3 4 Samir Jaber* , Boris Jung , Stefan Matecki and Basil J Petrof Abstract Diaphragmatic function is a major determinant of the ability to successfully wean patients from mechanical ventilation. However, the use of controlled mechanical ventilation in animal models results in a