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Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma
Wangetal.DiagnosticPathology2012,7:41
/content/7/1/41
RESEARCH
OpenAccess
ClinicopathologicalsignificanceofSOX4
expressioninprimarygallbladdercarcinoma
ChengguoWang?,HuadongZhao?,JianguoLu,JikaiYin,LiZang,NuanSong,RuiDong,TaoWu*andXilinDu*
Abstract
Aim:SOX4,asamemberoftheSRY-relatedHMG-box(SOX)transcriptionfactorfamily,hasbeendemonstratedto
beinvolvedintumorigenesisofmanyhumanmalignancies;however,itsroleinprimarygallbladdercarcinoma
(PGC)isstilllargelyunknown.TheaimofthisstudywastoinvestigateSOX4expressioninPGCanditsprognostic
significance.
Methods:From1997to2006,136patientsunderwentresectio
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