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Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock.docVIP

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Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock.doc

    Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock

    Donninoetal.CriticalCare2011,15:R189 /content/15/4/R189 RESEARCH OpenAccess CoenzymeQ10levelsarelowandmaybe associatedwiththeinflammatorycascadein septicshock MichaelWDonnino1,2*,MichaelNCocchi1,3,JustinDSalciccioli1,DanielKim1,AliBNaini4,CatherineBuettner5 andPraveenAkuthota2,6 Abstract Introduction:Mitochondrialdysfunctionisassociatedwithincreasedmortalityinsepticshock.CoenzymeQ10 (CoQ10)isakeycofactorinthemitochondrialrespiratorychain,butwhetherCoQ10isdepletedinsepticshock remainsunknown.Moreover,statintherapymaydecreaseCoQ10levels,butwhetherthisoccursacutelyremains unknown.WemeasuredCoQ1

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