Co-survival of the fittest few mosaic amplification of receptor tyrosine kinases in glioblastoma.docVIP

Chen and Ding Genome Biology 2012,13:141 /2012/13/1/141 RESEARCH HIGHLIGHT Co-survival of the ttest few: mosaic amplication of receptor tyrosine kinases in glioblastoma Feng Chen and Li Ding * 1 2,3 glioblastoma multiforme (GBM) (Figure 1) and achieved single-cell resolution, with regard to the selected target genes, in dissecting tumor heterogeneity. e discovery of mosaic ampli?cation of RTKs in GBMs has broad implications for tumor clonal evolution, the concept of driver mutations, and treatment choices. Abstract Mosaic