原创力文档Collagen-induced arthritis in common marmosets a new nonhuman primate model for chronic arthritis.docVIP
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Collagen-induced arthritis in common marmosets a new nonhuman primate model for chronic arthritis
Vierboometal.ArthritisResearchTherapy2010,12:R200
/content/12/5/R200
RESEARCH ARTICLE
OpenAccess
Collagen-inducedarthritisincommonmarmosets:
anewnonhumanprimatemodelforchronic
arthritis
MichelPMVierboom1*,EliaBreedveld1,IvanelaKondova2,BertA’tHart1,3
Abstract
Introduction:Thereisanever-increasingneedforanimalmodelstoevaluateefficacyandsafetyofnew
therapeuticsinthefieldofrheumatoidarthritis(RA).Particularlyfortheearlypreclinicalevaluationofhuman-
specificbiologicalstargetingtheprogressivephaseofthedisease,thereisaneedforrelevantanimalmodels.In
responsetothisrequirementwesetouttodevelopamodelof
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