Comprehensive analysis of human microRNA target networks.docVIP

SatohandTabunokiBioDataMining2011,4:17 /content/4/1/17 BioData Mining RESEARCH OpenAccess ComprehensiveanalysisofhumanmicroRNA targetnetworks Jun-ichiSatoh*andHirokoTabunoki *Correspondence:satoj@my- Abstract pharm.ac.jp DepartmentofBioinformaticsand MolecularNeuropathology,Meiji PharmaceuticalUniversity,2-522-1 Background:MicroRNAs(miRNAs)mediateposttranscriptionalregulationofprotein- codinggenesbybindingtothe3’untranslatedregionoftargetmRNAs,leadingto Noshio,Kiyose,Tokyo204-8588, Japan translationalinhibition,mRNAdestabilizationordegradation,dependingonthe degreeofsequencecomplementarity.I