Constitutive expression of cathepsin K in the human intervertebral disc new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.docVIP

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Constitutive expression of cathepsin K in the human intervertebral disc new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.doc

Constitutive expression of cathepsin K in the human intervertebral disc new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand

Gruberetal.ArthritisResearchTherapy2011,13:R140 /content/13/4/R140 RESEARCH ARTICLE OpenAccess ConstitutiveexpressionofcathepsinKinthe humanintervertebraldisc:newinsightintodisc extracellularmatrixremodelingviacathepsinK andreceptoractivatorofnuclearfactor- Bligand HelenEGruber1*,JaneAIngram1,GretchenLHoelscher1,NataliaZinchenko1,HJamesNorton2and EdwardNHanleyJr1 Abstract Introduction:CathepsinKisarecentlydiscoveredcysteineproteasewhichcleavesthetriplehelicaldomainsof typeItoIIcollagen.Ithasbeenshowntobeup-regulatedinsynovialtissuefromosteoarthriticandrheumatoid patients,andisacomponentinn

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Constitutive expression of cathepsin K in the human intervertebral disc new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.docVIP