Continuous infusion of antibiotics in the critically ill The new holy grail for beta-lactams and vancomycin.docVIP

VanHerendaeletal.AnnalsofIntensiveCare2012,2:22 /content/2/1/22 REVIEW OpenAccess Continuousinfusionofantibioticsinthecritically ill:Thenewholygrailforbeta-lactamsand vancomycin? BrunoVanHerendael1*,AxelJeurissen2,PaulMTulkens3,ErikaVlieghe4,5,WalterVerbrugghe6, PhilippeGJorens6andMargaretaIeven1 Abstract The alarming global rise of antimicrobial resistance combined with the lack of new antimicrobial agents has led to a renewed interest in optimization of our current antibiotics. Continuous infusion (CI) of time-dependent antibiotics has certain theoretical advantages toward efficacy based o