注射用泮托拉唑钠的稳定性考察.pdfVIP

·药品检验· 注射用泮托拉唑钠的稳定性考察 李军‘，部敬顺，张鉴(山东省立医院，济南市250021) 中图分类号 R927．11 文献标识码 A 文章编号 100卜0408(2005)2卜1655—03 摘要 目的：考察注射用泮托拉唑钠在4种输液中的稳定性。方法：采用高效液相色谱法测定注射用泮托拉唑钠与4种输液配伍 后在4h内的含量变化，并观察溶液外观；同时考察钾、镁、钙离子及pH值变化对注射用泮托拉唑钠稳定性的影响。结果：注射用泮 托拉唑钠在4种常用输液以及钾、镁、钙离子水溶液中于4h内其含量、外观、pH值、最大紫外吸收波长均无明显改变。溶液pH值 在4h内稳定。结论：注射用泮托拉唑钠在4种常用输液以及钾、镁、钙离子水溶液中于4h内可保持稳定，pH值对泮托拉唑钠溶液 的稳定性影响较大。 关键词注射用泮托拉唑钠；输液；pH值；离子；稳定性 onthe of Sodium Study StabilityInjectablePantoprazole LI Provincial Jun，BUJingshun，ZHANGJian(Shandong 250021，China) Hospital，ji’nan ABSTRACT the of ectable sodiumin4kindsof OBJECTIVE：To investigatestabilityinj pantoprazole AHPLCmethodwas inthis content of sodiumwasdetermined adopted determination，the injectable change pantoprazole within4 with4kindsofinfusionsandits ofcolorwas theeffectsof hours’mixing change observed；meanwhilepHvalue， ionsonthe of sodiumwere obvious potassium，magnesium，calcium stabilityinjectablepantoprazole werenotedintermsof maximum forthe changes wavelengthinjectablepan— contents，appearances，pHvalue，UV—absorption sodiumsolutionwithin4hourseitherin4kindsofcommoninfusionsorin ionswater toprazole was solutions．Itwas unstablewhenvalueof sodiumsolutionwaslowerthan7．0；whenits value extremely pH pantoprazole pH its value 7．0，itscolorbecame withoutobviouslOSSofcontent；itiSstablewithin4hwhen wasabove