Dodecatungstophosphoric Acid (H3PW12O40), Samarium and Ruthenium (？？？) Chloride Catalyzed Synthesis of Unsaturated 2-Phenyl-5(4H)-oxazolone Derivatives under Solvent-free Conditions.docVIP

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Dodecatungstophosphoric Acid (H3PW12O40), Samarium and Ruthenium (？？？) Chloride Catalyzed Synthesis of Unsaturated 2-Phenyl-5(4H)-oxazolone Derivatives under Solvent-free Conditions.doc

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Dodecatungstophosphoric Acid (H3PW12O40), Samarium and Ruthenium (？？？) Chloride Catalyzed Synthesis of Unsaturated 2-Phenyl-5(4H)-oxazolone Derivatives under Solvent-free Conditions

Molecules 2008, 13, 3246-3252; DOI: 10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Dodecatungstophosphoric Acid (H3PW12O40), Samarium and Ruthenium (???) Chloride Catalyzed Synthesis of Unsaturated 2-Phenyl-5(4H)-oxazolone Derivatives under Solvent-free Conditions Ahmad Momeni Tikdari 1,*, Samieh Fozooni 1 and Hooshang Hamidian 2 1 Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76135-133, Iran 2 Department of Chemistry, Payame Noor University (PNU), Kerman, Iran * Author to whom correspondence should be addressed; E-mail: amomeni_uk@. Received: 5 November 2008; in revised form: 27 November 2008 / Accepted: 16 December 2008 / Published: 18 December 2008 Abstract: We have found that dodecatungstophosphoric acid (H3PW12O40), samarium or ruthenium(III) chloride act as efficient catalysts for the synthesis of unsaturated 2-phenyl- 5(4H)oxazolone derivatives under solvent-free conditions. The key features of the reported protocols are short reaction times, high yields of products under ambient conditions and simple workups. Keywords: 2-Phenyl-5(4H)-oxazolone; Microwave irradiation; Samarium; Ruthenium(III) chloride; Dodecatungstophosphoric acid. Introduction Heterocyclic compounds have acquired more importance in recent years due to their pharmacological activities [1, 2] and nitrogen-, sulphur- and oxygen-containing five/six member heterocyclic compounds have achieved enormous significance in the field of Medicinal Chemistry. Oxazole plays a very pivotal role in the manufacture of various biologically active drugs with analgesic, anti-inflammatory, anti-depressant, anti-cancer, anti-microbial, anti-diabetic and antiobesity properties [3-5]. Molecules 2008, 13 3247 2-Phenyl-5(4H)-oxazolones are important intermediates in the synthesis of several molecules including amino acids, peptides, antimicrobial or antitumor