Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States.docVIP

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Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States.doc

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Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States

Nutrients 2012, 4, 1851-1867; doi:10.3390/nu4121851 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Article Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis: Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States Nelo Eidy Zanchi 1,2,3,*, Lucas Guimar?es-Ferreira 2, Mário Alves de Siqueira-Filho 2, Vitor Felitti 1, Humberto Nicastro 1, Carlos Bueno Jr. 4, Fábio Santos Lira 3, Marshall Alan Naimo 5, Patrícia Campos-Ferraz 1, Maria Tereza Nunes 2, Marília Seelaender 3, Carla Roberta de Oliveira Carvalho 2, Fran?ois Blachier 6 and Antonio Herbert Lancha Jr. 1 1 Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, 05508-030, Brazil; E-Mails: devfelitti@ (V.F.); frnicastro@usp.br (H.N.); pacamos@usp.br (P.C.-F.); resjr@usp.br (A.H.L.) 2 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-900, Brazil; E-Mails: lucas@cefd.ufes.br (L.G.-F.); deffmariofilho@ (M.A.S.-F.); kateresa@usp.br (M.T.N.); croc@icb.usp.br (C.R.O.C.) 3 Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of S?o Paulo, Sao Paulo, 05508-900, Brazil; E-Mails: yhfabioslira@ (F.S.L.); seelaenderrf@usp.br (M.S.) 4 Human Genome Research Center, Institute of Biosciences, University of S?o Paulo, S?o Paulo, 05508-900, Brazil; E-Mail: carmao11@.br 5 Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606, USA; E-Mail: mnaimo@ 6 INRA, CRNH-IdF, UMR 914, Nutrition Physiology and Ingestive Behavior, Paris, 78350, France; E-Mail: blachier@usp.br * Author to whom correspondence should be addressed; E-Mail: neloz@.br; Tel.: +55-11-3091-7247. Received: 28 September 2012; in revised form: 1 November 2012 / Accepted: 14 November 2012 / Published: 27 November 2012 Abstract: Dexamethasone (DEXA) is a potent immunosupressant and anti-infla