Electrical impedance tomography applied to assess matching of pulmonary ventilation and perfusion in a porcine experimental model.docVIP

Available online /content/13/2/R34 Research Open Access Vol 13 No 2 Electrical impedance tomography applied to assess matching of pulmonary ventilation and perfusion in a porcine experimental model Anneli Fagerberg, Ola Stenqvist and Anders ?neman Department of Anaesthesiology and Intensive Care, The Sahlgrenska Academy, Bla Straket 5, Gothenburg, SE 413 45, Sweden Corresponding author: Anders ?neman, anders.aneman@medfak.gu.se Received: 8 Oct 2008 Revisions requested: 21 Oct 2008 Revisions received: 27 Nov 2008 Accepted: 5 Mar 2009 Published: 5 Mar 2009 Critical Care 2009, 13:R34 (doi:10.1186/cc7741) This article is online at: /content/13/2/R34 ? 2009 Fagerberg et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Electrical impedance tomography (EIT) can be used to measure impedance changes related to the thoracic content of air and blood. Few studies, however, have utilised EIT to make concurrent measurements of ventilation and perfusion. This experimental study was performed to investigate the defined regions of interest (ROI) extending from the ventral to dorsal distance. Results A largely parallel distribution of Z and Z in all four V Q ROIs during baseline conditions corresponded to a bell-shaped frequency distribution of Z /Z ratios with only moderate feasibility of EIT to describe ventilation/perfusion (V/Q) V Q matching after acute changes of pulmonary perfusion and aeration. scatter. B and PEEP20 with unchanged tidal volumes infl significantly increased the mismatch of regional Z and Z , the V Q scatter of Z /Z ratios and the heterogeneity of the Z /Z Q negative V Q V Methods Six mechanically venti