Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis.docVIP

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Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis.doc

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Enhancedosteoclastdevelopmentincollagen-inducedarthritisininterferon-γreceptorknock-outmiceasrelatedtoincreasedsplenicCD11bmyelopoiesis

Arthritis Research Therapy Vol 6 No 3 De Klerck et al. Open Access Research article Enhanced osteoclast development in collagen-induced arthritis γ in interferon- receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis Bert De Klerck1, Isabelle Carpentier2, Rik J Lories3, Yvette Habraken4, Jacques Piette4, Geert Carmeliet5, Rudi Beyaert2, Alfons Billiau1 and Patrick Matthys1 1Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium 2Department of Molecular Biomedical Research, Ghent University – VIB, Ghent, Belgium 3Laboratory for Skeletal Development and Joint Disorders, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium 4Laboratory of Virology and Immunology, Institute of Pathology, University of Liège, Liège, Belgium 5Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium Corresponding author: Patrick Matthys (e-mail: patrick.matthys@rega.kuleuven.ac.be) Received: 12 Dec 2003 Revisions requested: 9 Jan 2004 Revisions received: 20 Feb 2004 Accepted: 24 Feb 2004 Published: 12 Mar 2004 Arthritis Res Ther 2004, 6:R220-R231 (DOI 10.1186/ar1167) ? 2004 De Klerck et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Collagen-induced arthritis (CIA) in mice is accompanied by from splenocytes of IFN-γR KO mice than from those of wild- type mice. This was not accompanied, as might have been expected, by increased concentrations of the intracellular adaptor protein TRAF6, known to be involved in signalling of RANKL- and TNF-α-induced osteoclast formation. Splenocyte cultures of IFN-γR KO mice also produced more TNF-α and more RANKL than those of wild-type mice. Finally, splenocytes splenomegaly d