轻度肾功能不全与冠状动脉病变程度的关系资料.docVIP

轻度肾功能不全与冠状动脉病变程度的关系 张 娟, 贾大林* 【摘要】 目的: 探讨轻度肾功能不全与冠状动脉狭窄程度的关系。方法：根据基础的肾小球滤过率（GFR）的不同将连续的272例接受冠状动脉造影且确诊为冠心病的患者分为两组（语序乱），肾功能正常组：GFR90ml/（min·1.73m2）135例，肾功能轻度下降组：60 ml/（min·1.73m2）GFR90ml/（min·1.73m2）137例。冠状动脉狭窄程度用造影图像处理系统测量，并计算其狭窄总积分，分析轻度肾功能不全与冠状动脉狭窄程度的定性与定量关系。结果：肾功能正常组冠状动脉病变积分为23.76±7.25 ，肾功能轻度减退组冠状动脉病变积分为26.87±18.69 ，两组之间比较后在统计学上有显著的差异（P0.05）肾小球滤过率与冠脉病变程度呈正相关（R=0.584）结论：轻度肾功能不全独立于其他冠心病的易患因素并且可作为预测冠状动脉病变严重程度的指标之一。 【关键词】轻度肾功能不全；冠心病 冠状动脉病变积分？/狭窄程度？ Relationship Between Mildrenal Dysfunction and Corouary Artery Stenosis Zhang Juan, Jia Dalin [ Abstract] Objective : To evaluate the relationship between mild renal dysfunction and coronary artery stenosis. Methods :272 cases of coronary artery stenosis undergoing coronary angiography were divided into two groups, the one is normal renal function group (Glomerular filtration rate, GFR90ml/（min·1.73m2）)and mild renal dysfunction group (Glomerular filtration rate, 60GFR90ml/（min·1.73m2) . The severity of coronary stenosis was quantified with angiography image manipulation system and scored according to lesions ,so to analyze the quantitive and qualitative relationship between mild renal dysfunction and coronaryartery stenosis. Results : the score of the coronary artery stenosis for the normal renal function group is23.76?.25, the score of the dcoronary artery stenosis for the mild renal dysfunction group is 26.87?8.69,there was a remarkable negative correlation between the two groups(p0.05) and there was a yremarkable negative correlation between mild renal dysfunction and coronary artery stenosis(r=0.584). Conclusion: Mild renal dysfunction was fully independent of other susceptible factors of coronary heart disease ,but was correlated with coronary artery stenosis. [ Key words] Mild renal dysfunction ; Coronary artery disease *通讯作者 （correspondent） 最早在Framingham[ 1 ]及NHANES I[ 2 ]等大型流行病学调查研究中发现合并慢性肾功能不全的冠心病患者的死亡率较肾功能正常的冠心病患者明显升高,但通过与其他已知的冠心病危险因素校正后回归分析结果却显示：肾功能不全对于死亡率在统计学上没有显著相关性。因此上述两项研究认为死亡率升高只是由于肾功能不全加重高血压、血糖及血脂代谢紊乱等危险