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Femtosecond Laser Microfabrication of an Integrated Device for Optical Release and Sensing of Bioactive Compounds.doc

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Femtosecond Laser Microfabrication of an Integrated Device for Optical Release and Sensing of Bioactive Compounds

Sensors 2008, 8, 6595-6604; DOI: 10.3390/s8106595 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Femtosecond Laser Microfabrication of an Integrated Device for Optical Release and Sensing of Bioactive Compounds Diego Ghezzi 1,2,?, Rebeca Martinez Vazquez 3, ?, Roberto Osellame 3,*, Flavia Valtorta 4,5, Alessandra Pedrocchi 1, Giuseppe Della Valle3, Roberta Ramponi 3, Giancarlo Ferrigno 1 and Giulio Cerullo 3 1 NeuroEngineering and Medical Robotics Laboratory, Bioengineering Department, Politecnico di Milano, 20133 Milano, Italy. E-Mails: diego.ghezzi@iit.it; alessandra.pedrocchi@polimi.it; giancarlo.ferrigno@polimi.it 2 Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, 16163 Genova, Italy 3 Istituto di Fotonica e Nanotecnologie (IFN) - CNR, Dipartimento di Fisica, Politecnico di Milano, 20133 Milano, Italy. E-Mails: rebeca.martinez@polimi.it; giuseppe.dellavalle@polimi.it; roberta.ramponi@polimi.it; giulio.cerullo@fisi.polimi.it 4 San Raffaele Scientific Institute and Vita-Salute University, 20132 Milano, Italy. E-Mail: flavia.valtorta@hsr.it 5 Unit of Molecular Neuroscience, The Italian Institute of Technology, 20132 Milano, Italy ? These authors contributed equally to this work * Author to whom correspondence should be addressed; E-Mail: roberto.osellame@polimi.it; Tel.: +39-02-2399-6075; Fax: +39-02-2399-6126 Received: 23 September 2008; in revised form: 16 October 2008 / Accepted: 21 October 2008 / Published: 23 October 2008 Abstract: Flash photolysis of caged compounds is one of the most powerful approaches to investigate the dynamic response of living cells. Monolithically integrated devices suitable for optical uncaging are in great demand since they greatly simplify the experiments and allow their automation. Here we demonstrate the fabrication of an integrated bio-photonic device for the optical release of caged compounds. Such a device is fabricated using femtosecond l