Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes.docVIP

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Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes.doc

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Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes

Available online /content/8/6/R171 Research article Open Access Vol 8 No 6 Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes Stefan Bauer1, Michael C Jendro2, Andreas Wadle1, Sascha Kleber1, Frank Stenner1, Robert Dinser3, Anja Reich2, Erica Faccin1, Stefan G?dde4, Harald Dinges5, Ulf Müller-Ladner3 and Christoph Renner1 1Oncology Department, Universit?tsSpital Zürich, R?mistrasse 100, 8091 Zürich, Switzerland 2Med. Department I, Universit?t des Saarlandes, Kirrbergstrasse, 66421 Homburg/Saar, Germany 3Department of Internal Medicine and Rheumatology, University of Giessen and Kerckhoff-Clinic, Benekestrasse 2–8, 61231 Bad Nauheim, Germany 4Orthopedic Department, Universit?t des Saarlandes, Kirrbergstrasse, 66421 Homburg/Saar, Germany 5Orthopedic Clinic, Westpfalz-Klinikum, Im Flur 1, 66869 Kusel, Germany Corresponding author: Stefan Bauer, stefan.bauer@usz.ch Received: 31 Mar 2006 Revisions requested: 10 May 2006 Revisions received: 2 Oct 2006 Accepted: 14 Nov 2006 Published: 14 Nov 2006 Arthritis Research Therapy 2006, 8:R171 (doi:10.1186/ar2080) This article is online at: /content/8/6/R171 ? 2006 Bauer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Fibroblast activation protein (FAP), as described so far, is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds. We investigated the expression of FAP by fibroblast-like synoviocytes (FLSs) and compared the synovial expression pattern in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Synovial tissue from diseased joints of 20 patients, 10 patients with refractory RA and 10 patients with e