结构生物学sturcture biology explore-50.pdfVIP

355 Functional transcriptomes: comparative analysis of biological pathways and processes in eukaryotes to infer genetic networks among transcripts Hidemasa Bono* and Yasushi Okazaki† Microarray technology enables us to monitor large changes in Microarray technology enables us to monitor multiple transcripts at any given time. The compilation of these data whole transcriptomes simultaneously [7]. The first definitive makes possible the comparison of such gene expression data example of this approach assessed the metabolic repro- on a genome-wide scale. As comparisons of genome sequence gramming that occurs during the diauxic shift in yeast [8]. data yield new biological insights, comparative analyses of Another important feature of this particular publication transcriptome data also promise new discoveries regarding was that all the data presented were accessible through metabolic pathways and cellular processes. The coordinated the Internet as supplementary data, thereby facilitating expression of genes shows that these genes physically interact subsequent, more advanced analyses. The main features of with each other or are part of the same cascade. We have transcriptome data are that they are dynamic and time- produced one of the largest expression profiles of adult mice dependent, whereas genome sequence data are static and developmental tissues. These data, as well as the data on and robust. This implies that the notion of comparison is yeast from previous reports, were used to see whether a more basic feature of the transcriptome data. In this coordinated expression (with high correlation co