严重乙型肝炎活动进展为肝衰竭的预后因素分析.pdfVIP

Chinese Journal of Zoonoses DOI 10 3969cjz issn 1002 2694 2014 12 010 j Logistic HBV PC GA BCP A T GA TB mol dL P PTA P HBeAg P PC P HBeAg PC HBV R373 2 A 1002 2694 2014 12 1218 05 Serum total bilirubin rothrombin HBeAg and PC mutant redictors p p of severe acute exacerbation in patients with chronic hepatitis B YANG Ling JIAO Qian ZENG Wenting LIANG Zengwei XIE Xueshuo Dep artment of Inf ectious Diseases the First A f f iliated Hosp ital Guangz hou Medical Universit y Guangz hou China Hep atology Unit and Dep artment of Inf ectious Diseases N anf ang Hosp ital Southern Medical University Guangz hou China ABSTRACT In this study we elucidated the predictors of progression to liver failure during severe acute exacerbation We analyzed consecutive patients with severe acute exacerbation of chronic hepatitis B for clinical outcome and factors that influ enced the development of liver failure including viral genotype PC GA and BCP AT GA mutants Thirty three severe acute exacerbation patients progressed to liver failure M ultivariate analysis identified serum bilirubin TB mol dL P and prothrombin activity PTA P as significant determinants of progression to liver failure HBeAg negativity P and PC mutant P were associated with the progression to hepatic de compensation Serum total bilirubin rothrombin activities HBeAg status and PC mutant were predictors of clinical outcome