乳腺癌患者血清中CEA和CA153的表达及临床意义_0.docVIP

乳腺癌患者血清中CEA和CA153的表达及临床意义 【关键词】 乳腺肿瘤；癌胚抗原；CA 　　Expressions of CEA and CA153 in the serum of breast cancer patients and thEir clinical significances 　　【Abstract】 AIM: To study the correlations between the expressions of carcinoembryonic antigen （CEA）and CA153 in the serum of breast cancer patients and the genesis, growth and metastasis of breast tumor. METHODS: We collected the serum from 60 patients, including 40 of breast cancer and 20 of benign breast diseases, and then detected the expressions of CEA and CA153 with radioimmunoassay. RESULTS: In 40 breast cancer patients, and the positive rates of CEA and CA153 were 32.5% and 47.5% respectively, the contents of CEA and CA153 were (21.55±6.96) μg/L and (37.63±23.22) U/mL respectively;they were obviously higher than those in the control group (20 benign breast disease patients) （P0.01）. The re were positive correlations between the contents of CEA and CA153 and the histological grade, tumor size and the axillary lymph node metastasis (P0.01). CONCLUSION: CEA and CA153 have close relations with the genesis, growth, biological behavior and metastasis of breast tumor. The comprehensive detection of these indexes is useful for the early diagnosis and beneficial for a good prognosis of breast cancer patients. 　　【Keywords】 breast neoplasms; carcino embryonic antigen; CA153 antigen; radioimmunoassay 　　【摘要】 目的： 研究 乳腺癌患者血清中癌胚抗原（CEA）和癌相关粘蛋白抗原（CA153）表达与肿瘤的发生 发展 与转移的关系及其临床意义. 方法 ： 采集60例乳腺疾病入院患者的血清样本，其中乳腺癌40例，乳腺良性疾病20例，用放射免疫 分析 方法检测其血清中CEA和CA153含量. 结果： 在40例乳腺癌患者血清中CEA和CA153的阳性率分别为32.5%和47.5%, CEA和 CA153的血清含量分别为(21.55±6.96) μg/L和(37.63±23.22) U/mL，均高于对照组（P0.01），乳腺癌患者CEA和CA153血清含量和阳性率与组织学分级，肿瘤大小，腋窝淋巴结转移有关（P0.01）. 结论： CEA和 CA153与乳腺癌的发生、发展，生物学特征以及转移有一定相关性，联合检测这些指标对乳腺癌的早期诊断和愈后判断有一定临床意义. 　　【关键词】 乳腺肿瘤；癌胚抗原；CA153抗原；放射免疫测定 　　0引言 　　乳腺癌是严重威胁妇女生命的常见恶性肿瘤，近年来其发病率呈逐年上升趋势，在某些大成市中已占妇女恶性肿瘤的首位［1］. 早期诊断与 治疗 ，早期发现复发与转移，对乳腺癌的预后有重要意义. 肿瘤标志物癌胚抗原（CEA）可见于乳腺癌组织细胞表面，细胞表面糖蛋白（CA153）是 目前 乳腺癌的首选肿瘤标志物. 本研究 应用 放射免疫分析方法检测CEA和CA153在乳腺癌中的表达，探讨两者在乳腺癌发生发展中的作用，为乳腺癌