子宫内膜异位症血清和囊液CA125的测定.docVIP

子宫内膜异位症血清和囊液CA125的测定 【摘要】 目的 探讨CA125与子宫内膜异位症(EM)的关系。 方法 分别对卵巢子宫内膜异位囊肿（ECO组）和非EM的卵巢良性囊肿患者(对照组)血清及囊液CA125水平进行测定。结果 ECO组囊液CA125水平高于血清CA125水平（P0.01）；ECO组血清和囊液CA125水平均高于对照组（P0.01）；且血清和囊液CA125水平与病情程度成正相关（r分别为0.86和0.81，P0.01）；血清CA125与痛经严重程度呈正相关（r=0.56，P0.01）；而囊液CA125水平与痛经严重程度无明显相关性（r=0.07，P0.05）。结论 CA125与EM的发生、 发展 及预后有关；CA125随着病情程度增加而升高，血清CA125与痛经程度呈正相关，测定血清CA125有助于EM的诊断及病情、预后的判断。 【关键词】 子宫内膜异位症 血清 囊液 CA125 实验室检查 Abstract: Objective To assess the relationship between CA125 concentrations with endometriosis (EM). Methods The serum and cyst fluid CA125 levels in patients with endometriosis cyst of ovary (ECO group) and benign cyst of ovary (non-EM, control group) were measured. Results Cyst fluid CA125 levels were significantly higher in ECO group, compared to serum CA125 levels (P0.01). Both serum and cyst fluid CA125 levels were significantly higher in ECO group than those in control group (P0.01). Additionally, serum and cyst fluid CA125 were associated positively with the disease state (r=0.86 and 0.81, respectively, P0.01). Serum CA125 was associated positively with dysmenorrhea degree (r=0.56, P0.01), and cyst fluid CA125 had no association with severity of dysmenorrhea (r=0.07, P0.05). Conclusion CA125 is related with the genesis, progress and prognosis of EM; the worse the disease was, the more elevated CA125 was found, serum CA125 is associated positively with the dysmenorrhea degree. Serum CA125 can be used as a marker for diagnosing and predicting the prognosis of disease. 　　Key words: endometriosis; blood serum; cyst fluid; laboratory examination 子宫内膜异位症(endometriosis, EM)是妇产科多发病和常见病，许多 研究 发现EM患者血清CA125水平升高，揭示该指标对EM的发病和诊断具有重要价值，而EM囊肿囊液CA125与EM的关系研究 文献 报道较少。本实验通过测定卵巢子宫内膜异位囊肿(endometrial cysts of the ovary，ECO)囊液和血清CA125水平, 分析 其与EM病情、痛经的关系，旨在进一步探讨EM的发病机理及CA125在EM中的诊断意义。 　　1 对象与方法 　　1.1 研究对象 　　52例ECO患者，均经病理检查证实。年龄19～50岁。按1985年美国生育协会（AFS）提出修正的EM分期法进行临床分期［1］。痛经评分：所有EM患者均进行痛经评分，评分标准参照文献［2,3］。具体方法：0分：无痛经；1分：有痛经，不需服药，不 影响 日常生活和工作；2分：痛经需用药物缓解，对日常生活及工作有影响