nextseq500系统揭示疾病机制-NextSeq500System.PDF

June 2015 Unraveling Disease Mechanisms With The ® NextSeq 500 System Researchers at the Icahn School of Medicine at Mount Sinai are studying mtDNA, piRNA, and TCR repertoire diversity to unlock the secrets of cancer, infertility, and autoimmune disease. Introduction The chair of genetics at Mount Sinai Hospital recruited me 5 years ago to build upon the strictly computational work that I had been doing Extensive research is focused on how human genome aberrations at Cold Spring Harbor. When I made the move, they were thinking contribute to the onset and progression of disease. Structural of starting a sequencing program and the responsibility for setting it variations, gene mutations, deletions, and insertions have all been up fell into my hands. I hired a technician and together we learned found to play a role. Yet up until recently, researchers have been a lot about sequencing systems and workflows as we established limited in studying how genetic changes in the DNA or RNA driving the laboratory. specific biological subsystems might be involved in disease onset and progression. Q: How are your team’s research goals intertwined with the An innovative research team at the Icahn School of Medicine at Mount development of new sequencing metho