CC趋化因子(国外英文资料).doc

CC趋化因子 NK cells can be activated in multiple ways, including CD2, CD3 and multiple cytokines on the surface of the membrane. 1. Through the CD3 molecules zeta chain NK cells no expression of TCR/CD3 complex, but part of NK cells expressed CD3 zeta chain, when using CD16 antibody stimulating NK cell activation, zeta chain tyrosine phosphorylation, cause intracytoplasmic Ca?? 2 +? Increases in concentration and IP3 levels increase the role of cytokine synthesis and ADCC. Using CD2 molecular CD2 to interact with the CD58 and stimulate the NK cells with CD2 McAb, the CD3 zeta chain occurs with tyrosine phosphorylation. Natural killer cell stimulation factor (NKSF) has a stimulating effect on NK cells. IL - 2, IL - 12, interferons alpha, TNF alpha and white blood cells, regulating element (leukoregulin, LR) on NK cell activation and differentiation are regulation, to join the cells in vitro culture factor can obviously improve the killing activity of NK. Prostaglandins (PG) E1, E2, D2, and corticosteroids inhibit the activity of NK cells. The NK cell surface has il-2 affinity receptor, and il-2 induces NK to be activated for approximately 18 to 24 hours. Moreover, IL - 2 can also induce NK cell proliferation, generally 3 ~ 4 days after stimulus began to proliferate, its mechanism is to induce NK cells, IL - 2 expression of IL - 2 r alpha chain, a new expression of alpha beta chain on the surface of the chain with original cell and gamma chain to form high affinity receptor, in the presence of IL - 2 stimulus NK cells proliferate. IL - 2 the activity of NK cells induced mechanism is not clear, may be related to increase the expression of cell adhesion molecules, increase killing activity of NK resistant to target cells, may also increase the NK cell particles in the cytoplasm and serine esterases mRNA expression, activation and promote the role of killer medium. Edit the function of the four, NK cells (1) natural killing activities Since NK cells do not have an MHC restr