呼吸高兴剂(国外英文资料).docVIP

呼吸兴奋剂 Respiratory stimulant Respiratory stimulant belongs to, mainly through direct excited medulla oblongata respiratory center, also can through the stimulation of carotid body and aortic body chemoreceptor reflex sexual excitement respiratory center, quickened breathing deepened, increase ventilation, improves the blood oxygen partial pressure, to reduce the co2 partial pressure in the blood. Increasing the sensitivity of the respiratory center to carbon dioxide is particularly exciting when the respiratory center is inhibited. The basic concept Physiological response analysis Usually, PaO2 and PaCO2 rise has strong stimulation of respiratory center, lack of oxygen and CO2 increase compared to the latter is usually the main factor causing respiratory center excited. But when in severe respiratory failure, the sensitivity of the respiratory center of CO2 is reduced, the stimulation of CO2 increase is no longer the main factor causing respiratory center excited, now relies mainly on the low oxygen to stimulate chemoreceptor reflex sexual excitement respiratory center, in order to maintain its excitability. If given oxygen, oxygen to the respiratory center of excitation is eliminated, the result instead of respiratory center is restrained, and the redistribution of blood flow to the lungs, invalid cavity increase factors such as ventilation, make PaCO2 more elevated. In addition, if combined with the application of respirable stimulants, we can avoid the respiratory inhibition caused by oxygen therapy, and achieve the goal of correcting hypoxia and CO2 retention in time. As a result, the use of respirable stimulants to reduce PaCO2 and increase the use of oxygen will still have therapeutic value. Application of indications The principle for use of 1. Mainly apply to the central inhibition, inadequate ventilation of respiratory failure, for pneumonia, pulmonary edema, diffuse pulmonary fibrosis and other pathological changes is given priority to with pulmonary venti