聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临.PDF

聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临 床观察 ＊ 陈永志 ，邓树忠（攀枝花市中心医院，四川攀枝花 617067） + 中图分类号 R975.3 文献标志码 A 文章编号 1001-0408（2015）09-1199-03 DOI 10.6039/j.issn.1001-0408.2015.09.18 摘 要 目的：观察聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临床疗效和安全性。方法：将144例老年功能性 便秘患者随机均分为A 、B 、C 组。A 组患者给予双歧杆菌三联活菌散1g ，B 组患者给予聚乙二醇4000散10g ，C 组患者给予双歧 杆菌三联活菌+聚乙二醇4000散，于早、晚餐后口服。各组患者疗程均为4周。观察各组患者的临床疗效，药物起效时间，大便形 态恢复正常时间，第2、4周大便次数，治疗前后各临床症状评分及不良反应发生情况。结果：C 组患者总有效率显著高于A 、B 组， 且药物起效时间及第2、4周大便次数均显著多于A 、B 组，大便形态恢复正常时间显著短于A 、B 组，差异均有统计学意义（P ＜ 0.05）。治疗后各组患者各临床症状评分均显著低于同组治疗前，且C 组低于A 、B 组，差异均有统计学意义（P ＜0.05）。各组患者 治疗期间均未见严重不良反应发生。结论：聚乙二醇散联合双歧杆菌三联活菌散较单用聚乙二醇散或双歧杆菌三联活菌散疗效 更为显著，安全性较好。 关键词 老年；功能性便秘；聚乙二醇散；双歧杆菌三联活菌散；疗效 Clinical Observation of Polyethylene Glycol Combined with Bifidobacterium Triple Viable in the Treatment of Elderly Functional Constipation CHEN Yong-zhi ，DENG Shu-zhong （Panzhihua Central Hospital ，Sichuan Panzhihua 617067，China ） ABSTRACT OBJECTIVE ：To observe the clinical efficacy and safety of polyethylene glycol combined with bifidobacterium tri- ple viable in the treatment of elderly functional constipation. METHODS ：A total of 144cases of elderly patients with functional con- stipation were randomly divided into group A ，B and C. Group A was treated with oral administration of bifidobacterium triple via- ble 1 g after breakfast and dinner ；group B were treated with oral administration of polyethylene glycol 4000 10g after breakfast and dinner ；group C were treated with oral administration of polyethylene glycol 4000 combined with bifidobacterium triple viable （the same usage and dosage as group A and B ）. The course was 4 weeks. The clinical efficacy ，drug onset time ，defecation form normal time ，defecation times in 2and 4weeks ，clinical symptoms scores and adverse reactions before and after treatment were ob- served. RESULTS ：The total effective rate of group C was significa