抗蛋白吸附PLLA_MPEG微绒毛膜的制备.pdf

Vol. 23 No. 3 2010 9 Journal of Functional Polymer s 215 PLLAMPEG 赵 媛, 徐首红, 刘洪来 ( 华东理工大学化学系, 结构可控先进功能材料及其制备教 部重点实验室, 上海200237) : 在左旋聚乳酸( PLLA) 膜上采用朗格缪尔布洛杰特( LB) 技术浇铸和化学接枝的方法 制备了左旋聚乳酸甲基端聚乙二醇( PLLAMPEG) 共聚物微绒毛膜通过原子力显微镜( AFM) 和水接触角测量等方法考察了制备方法及条件对绒毛层性能的影响, 对绒毛层的亲水性稳定性和 抗蛋白吸附性能进行了对比分析结果表明: 通过这3 种方法均能获得较亲水的抗蛋白吸附表面 PLLAMPEG 单分子LB 微绒毛必须在热水中处理后才能牢固地黏附于PLLA 膜上; 浇铸的 PLLAMPEG成膜性好, 但遇水易脱落, 稳定性差; 紫外光催化接枝的微绒毛制备简便铆接牢固, 可用于医疗器械或生物埋置材料的表面修饰 : 微绒毛膜; 抗蛋白吸附; 聚乳酸聚乙二醇共聚物; 表面修饰 : O6 : A : 2010) Preparation of PLLAMPEG Microbrushes for Resistance of Protein Adsorption ZHAO Yuan, XU Shouhong, LIU Honglai ( Key Laboratory for Advanced M aterials and Department of Chemistry , East China U niversity of Science and T echnology, Shanghai 200237, China) Abstract: Poly(L lactic acid)copoly( ethylene glycol) ( PLLAMPEG) microbrushes w ere prepared by LB technique, casting and chemical grafting onto PLLA films. T he effects of preparing conditions on the pro perties of microbrush layers w ere studied by atomic force microscope ( AFM) and water contact angle. The stability, hydrophilicity and protein resistance ability of these microbrush layers w ere also thoroughly studied and compared. Results show that PLLAMPEG microbrush layers prepared by the three methods are all hydrophilic and show resistance of protein adsorption. PLLAMPEG LB film is dealt w ith hot w ater to increase its stability. The casting PLLAMPEG layer has a good filming property but the stability is bad. T he microbrushes prepared by photocatalysis method could bind firmly on PLLA casting film, w hich is possible to be used in surface modification of medical devices and implanting materials. Key words: microbrush; resistance of protein adsorp