戊四氮点燃过程中大鼠海马苔藓纤维发芽变化的研究_朱遂强.pdfVIP

# 6 # Chinese Jo rnal of Rehabilitation, Febr ary 2004, Vol. 19 No. 1 * 朱遂强, 杨嘉君, 杜鹏, 王开颜, 阮旭中 ( 华中科技大学同济医学院附属同济医院神经内科, 湖北武 430030) = : ( PTZ) :450 ( PTZ 35mg/ kg , 1 ) ( 30 mg/ kg PTZ 35 mg/ kg , 1 ) , Timm 3 : PTZ , , , CA3 , , ( P 0. 05) , , ( P 0.05) : - PTZ , , = ; ; ; = R742. 1 = A = 1001-2001(2004) 01-0006-03 Investigation on the Variation of the Mossy Fiber Sprouting in Hippocampus of Pentylenetrazol Kindling Rats ZH U Sui-qiang, YANG Jia-j un, DU Peng, et al1Department of Neurology , Tongj i Hosp ital, Tongj i edical College, Huazhong University of Science and Technology , W han 430030, China = Abtract Objective: To investigate the relationship betw een the plasticity of cell modality in m rine hippocamp s and the pathogenesis of chronic epilepsy d ring the pentylenetrazol (PTZ) kindling process. Methods: 450 rats were ran- domly divided into 3 gro ps: control gro p, PTZ-treated gro p ( PTZ 35 mg/ kg, intraperitoneal injection, once every day) and intervent ion gro p ( phenobarbital 30 mg/ kg and PTZ 35 mg/ kg, intraperitoneal injection, once every day) . T he mossy fiber spro ting in hippocamp s d ring the kindling process w as observed by Timm silver staining and the dif- ference among the 3 gro ps w as analyzed. Res lts: D ring the latent period of PTZ-kindling before the occ rrence of con- v lsion confirmed by behavior and EEG, abnormal mossy fiber spro t ing w as observed in the inner molec lar layer of the dentate gyr s and the transparent layer of CA3 section of the hippocamp s in PTZ-treated gro p. T here were significant difference between PTZ-treated gro p and control gro p or intervention gro p at the corresponding time points ( all P 0. 05) . Concl sion: Mossy fiber spro ting and plasticit y of cell mo