不同剂量复方甘草酸苷联合拉米夫定治疗慢性乙型病毒性肝炎临床观察.doc

不同剂量复方甘草酸苷联合拉米夫定治疗慢性乙型病毒性肝炎的临床观察 　　[摘要]目的 探讨不同剂量复方甘草酸苷联合拉米夫定治疗慢性乙型病毒性肝炎的临床效果。方法 选取我院2013年1月～2015年12月收治的150例慢性乙型病毒性肝炎患者作为研究对象，随机分为A、B、C三组，各50例。三组均接受拉米夫定治疗，A组同时接受40 ml复方甘草酸苷治疗，B组同时接受60 ml复方甘草酸苷治疗，C组同时接受80 ml复方甘草酸苷治疗，比较三组的治疗效果。结果 C组治疗后的肝区不适、乏力、食欲不振、肝肿大等症状和体征改善率以及不良反应发生率高于A组和B组，B组治疗后的肝区不适、乏力、食欲不振、肝肿大等症状和体征改善率以及不良反应发生率高于A组，差异有统计学意义（P0.05）。结论 慢性乙型病毒性肝炎患者接受拉米夫定联合大剂量复方甘草酸苷治疗，有助于患者肝功能的改善以及临床症状和体征的减轻，临床应用价值较高 [关键词]复方甘草酸苷；拉米夫定；慢性乙型病毒性肝炎；肝功能 [中图分类号] R512.6+2 [文献标识码] A [文章编号] 1674-4721（2016）10（b）-0120-04 [Abstract]Objective To explore the clinical effect of different doses of Compound Glycyrrhizin Glucoside in combination with Lamivudine in the treatment of chronic hepatitis B viral hepatitis.Methods 150 patients with chronic hepatitis B viral hepatitis in our hospital from January 2013 to December 2015 were selected and randomly divided into group A，group B and group C，50 cases in each group.All patients were treated with Lamivudine，group A was treated with 40 ml Compound Glycyrrhizin Glucoside at the same time，while group B was treated with 60 ml Compound Glycyrrhizin Glucoside at the same time，group C was treated with 80 ml Compound Glycyrrhizin Glucoside at the same time.The therapeutic effect was compared between the three groups.Results The symptoms and signs improvement rate of liver discomfort，fatigue，loss of appetite，hepatomegaly after treatment and the incidence rate of adverse reaction in group C was higher than that in group A and group B，the symptoms and signs improvement rate of liver discomfort，fatigue，loss of appetite，hepatomegaly after treatment and the incidence rate of adverse reaction in group B was higher than that in group A，with significant difference （P0.05）.Conclusion Patients with chronic hepatitis B viral hepatitis treated with Lamivudine combined with high dose of Compound Glycyrrhizin Glucoside，which can help to improve the patient′s liver function，reduce clinical symptoms and signs，with the higher clinical application value. 　　[Key words]C